Ulcer in corner of mouth 1st sign of monkeypox virus infection, Health News, ET HealthWorld

New Delhi: Ulcer at the corner of the mouth has now been documented by scientists as the first sign of monkeypox virus infection.

A recent monkeypox virus infection may initially show very few pronounced clinical symptoms and no signs of infection, and only a few skin blisters may be visible.

German researchers have now presented the case of a 51-year-old HIV-positive patient, whose ulcer at the corner of his mouth emerged as the first sign of monkeypox virus infection.

According to Stefan Schlabe, University Hospital Bonn, Department of Medicine, and colleagues, the patient presented to his GP with a blister in the left corner of his mouth that had appeared the day before.

“He had no clinical signs of infection; his HIV infection had been well controlled for years, both virologically and immunologically, with antiretroviral therapy,” says the study published in the journal Deutsches Arzteblatt. international.

Initially, the patient’s ulcer was treated with a topical combination ointment.

Within days, he developed a painful ulcer in the left corner of his mouth and returned to see his GP. A swab was taken from the ulcer.

“Polymerase chain reaction (PCR) tests confirmed the monkeypox virus. Subsequently, an increase in monkeypox vesicles was noted on the skin, but also on the palate,” the researchers noted.

With increasing swelling at the base of the tongue and muffled speech, it was decided to admit the patient to hospital for antiviral treatment with tecovirimat, they added.

The monkeypox outbreak continues to be a global health emergency, which is the highest alert level according to the World Health Organization (WHO).

There have so far been nearly 80,000 recorded cases in 106 countries, with 36 deaths.