Simple skin biopsy can assess blood clots linked to Covid-19, Health News, ET HealthWorld

New York: Researchers used a noninvasive skin biopsy to identify clots in small venous and arterial blood vessels in the skin of patients with severe Covid-19 who appeared normal.

The clots, however, were not seen in the skin of patients with other types of severe infectious lung disease, or in individuals with only mild or moderate Covid, the findings published in The American Journal of Pathology revealed.

Prior to this study, researchers used invasive procedures such as nerve, kidney, or lung biopsy.

“We were the first group to recognize that acute Covid-19 lung disease was different from other severe critical respiratory infections, and that the unusual pathology was systemic,” lead researcher Jeffrey Laurence, Department of Medicine, explained to Weill. Cornell Medicine, US.

For the study, the team collected simple 4mm punch biopsy specimens of normal-appearing deltoid skin from 15 patients who were in intensive care with Covid and six patients with mild to moderate Covid symptoms. , such as fever, chills, cough or shortness of breath. breath.

Biopsy specimens from nine hospitalized patients with severe or critical respiratory or kidney disease who died before the Covid era were also included in the study.

Microthrombi were detected in 13 of 15 patients with severe or critical Covid-19. No microthrombi were detected in biopsies of patients with mild to moderate Covid or pre-Covid-era patients with severe respiratory disease or kidney disease. It is likely that these microvascular changes are a unique feature of Covid respiratory disorder compared to other acute respiratory illnesses.

An antiviral protein capable of blocking the growth of Covid, MxA, was found in all six mild to moderate Covid patients, indicating that their immune systems were actively fighting the virus, compared to only two patients with severe to critical illness.

An interferon-induced inflammatory protein, SIN3A, was prominent in the microvasculature of normal-appearing skin from patients with severe or critical Covid, but not in similar samples from normal control subjects.

Increased plasma SN3A levels and expression in the skin microvasculature were associated with patient disease severity and may contribute to the characteristic cytokine storm in these patients.

“If validated in a longitudinal cohort, earlier identification of factors related to severe Covid-19 using a simple skin biopsy in patients in the early stages of SARS-CoV-2 infection can help identify individuals at risk for acute disease progression and long Covid and enable targeted early interventions,” Laurence said.