Landmark study reveals that antiseptic agents interc

New Orleans, LA – LSU Health New Orleans School of Orthopedics participated in a study comparing two antiseptic aqueous solutions to reduce the risk of infection in patients requiring surgery for open fractures. In the largest known randomized controlled trial, the research team found that contrary to current international recommendations, chlorhexidine gluconate was not superior to povidone iodine in an alcohol or aqueous solution in preventing site infection. operative. Findings suggesting that healthcare practitioners can choose either aqueous antiseptic solution when treating open fractures based on solution availability, patient contraindications, or product cost are published in The Lancetavailable here.

Robert Zura, MD, professor and chief of orthopedics, and Jessica Rivera, MD, PhD, associate professor of orthopedics, at LSU Health New Orleans School of Medicine, are also co-authors of the article.

“I am proud of the contributions of Dr. Rivera and LSU Health New Orleans to this landmark study published in such a prestigious journal,” says Dr. Zura.

The authors point to WHO estimates of the millions of patients worldwide each year who have surgical site infections. The inherent risk of using fracture fixation in a contaminated or dirty wound is realized in approximately 10% of open fractures developing surgical site infections. Orthopedic surgical procedures have the highest infection rate, exceeding 20% ​​for severe open fractures of the shaft of the tibia.

Previous reviews of trials in general surgery, obstetrics, and gynecology have suggested the superiority of chlorhexidine over iodine. The multi-period, cluster-randomised, Aqueous-PREP

The crossover trial included 14 hospitals in Canada, Spain and the United States and 1,638 adults who underwent surgery for an open limb fracture. It found that the risks of surgical site infection or unplanned fracture-related reoperations did not differ between patients assigned to receive skin antisepsis with 10% aqueous povidone or 4% aqueous chlorhexidine gluconate. . The authors wrote, “Our results contrast with the superiority of chlorhexidine over alcohol that has been demonstrated in clean or clean and contaminated surgery.”

The authors note that their findings may be particularly relevant for low- and middle-income countries, where both antiseptic solutions may not be readily available or procure both.

products is unnecessarily expensive.

They conclude: “Our results are not only relevant for the management of open fractures, but could also be applicable to the surgical treatment of other traumatic wounds.”

This study was funded by the United States Department of Defense, the Canadian Institutes of Health Research, McMaster University Surgical Associates and the PSI Foundation.


LSU New Orleans Health Sciences Center educates Louisiana healthcare professionals. The state’s flagship health sciences university, LSU Health New Orleans, includes a medical school with campuses in Baton Rouge and Lafayette, the only dental school in the state, the only public health school Louisiana Public and Allied Health, Nursing, and Graduate Schools. Studies. LSU Health New Orleans faculty care for patients at public and private hospitals and clinics across the region. At the forefront of bioscience research in a number of fields on the world stage, the LSU Health New Orleans research enterprise generates jobs and enormous economic impact. LSU Health New Orleans faculty have made life-saving discoveries and continue to work to prevent, advance treatment, or cure disease. To learn more, visit,

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